Ontology highlight
ABSTRACT:
SUBMITTER: Zhang Z
PROVIDER: S-EPMC5910022 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Zhang Zhening Z Liang Wenguang G WG Bailey Lucas J LJ Tan Yong Zi YZ Wei Hui H Wang Andrew A Farcasanu Mara M Woods Virgil A VA McCord Lauren A LA Lee David D Shang Weifeng W Deprez-Poulain Rebecca R Deprez Benoit B Liu David R DR Koide Akiko A Koide Shohei S Kossiakoff Anthony A AA Li Sheng S Carragher Bridget B Potter Clinton S CS Tang Wei-Jen WJ
eLife 20180329
Insulin degrading enzyme (IDE) plays key roles in degrading peptides vital in type two diabetes, Alzheimer's, inflammation, and other human diseases. However, the process through which IDE recognizes peptides that tend to form amyloid fibrils remained unsolved. We used cryoEM to understand both the apo- and insulin-bound dimeric IDE states, revealing that IDE displays a large opening between the homologous ~55 kDa N- and C-terminal halves to allow selective substrate capture based on size and ch ...[more]