Ontology highlight
ABSTRACT:
SUBMITTER: Kakkar N
PROVIDER: S-EPMC5910287 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Kakkar Nidhi N Perez Jessica G JG Liu Wenshe R WR Jewett Michael C MC van der Donk Wilfred A WA
ACS chemical biology 20180221 4
Lantibiotics are ribosomally synthesized and post-translationally modified peptide natural products that contain thioether cross-links formed by lanthionine and methyllanthionine residues. They exert potent antimicrobial activity against Gram-positive bacteria. We herein report production of analogues of two lantibiotics, lacticin 481 and nisin, that contain nonproteinogenic amino acids using two different strategies involving amber stop codon suppression technology. These methods complement rec ...[more]