Ontology highlight
ABSTRACT:
SUBMITTER: Chibly AM
PROVIDER: S-EPMC5910385 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Chibly Alejandro M AM Wong Wen Yu WY Pier Maricela M Cheng Hongqiang H Mu Yongxin Y Chen Ju J Ghosh Sourav S Limesand Kirsten H KH
Scientific reports 20180420 1
Xerostomia and salivary hypofunction often result as a consequence of radiation therapy for head and neck cancers, which are diagnosed in roughly 60,000 individuals every year in the U.S. Due to the lack of effective treatments for radiation-induced salivary hypofunction, stem cell-based therapies have been suggested to regenerate the irradiated salivary glands. Pharmacologically, restoration of salivary gland function has been accomplished in mice by administering IGF-1 shortly after radiation ...[more]