Ontology highlight
ABSTRACT:
SUBMITTER: Aurisicchio L
PROVIDER: S-EPMC5910567 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Aurisicchio Luigi L Pallocca Matteo M Ciliberto Gennaro G Palombo Fabio F
Journal of experimental & clinical cancer research : CR 20180420 1
In the advent of Immune Checkpoint inhibitors (ICI) and of CAR-T adoptive T-cells, the new frontier in Oncology is Cancer Immunotherapy because of its ability to provide long term clinical benefit in metastatic disease in several solid and liquid tumor types. It is now clear that ICI acts by unmasking preexisting immune responses as well as by inducing de novo responses against tumor neoantigens. Thanks to theprogress made in genomics technologies and the evolution of bioinformatics, neoantigens ...[more]