Ontology highlight
ABSTRACT:
SUBMITTER: Cohen SIA
PROVIDER: S-EPMC5911155 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Cohen Samuel I A SIA Cukalevski Risto R Michaels Thomas C T TCT Šarić Anđela A Törnquist Mattias M Vendruscolo Michele M Dobson Christopher M CM Buell Alexander K AK Knowles Tuomas P J TPJ Linse Sara S
Nature chemistry 20180326 5
Mapping free-energy landscapes has proved to be a powerful tool for studying reaction mechanisms. Many complex biomolecular assembly processes, however, have remained challenging to access using this approach, including the aggregation of peptides and proteins into amyloid fibrils implicated in a range of disorders. Here, we generalize the strategy used to probe free-energy landscapes in protein folding to determine the activation energies and entropies that characterize each of the molecular st ...[more]