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You can't fix what isn't broken: eight weeks of exercise do not substantially change cognitive function and biochemical markers in young and healthy adults.

ABSTRACT: Objective:The benefits of exercise on brain health is well known in aging and psychiatric populations. However, the relationship between habitual exercise in young and healthy adults remains unclear. This study explored the effects an eight-week exercise prescription on cognitive function, brain-derived neurotrophic factor (BDNF) and cathepsin B (CTHB) in young and healthy adults. Methods:A total of 22 low-active, young and healthy adults were recruited from a local university. A total of 12 participants performed an eight-week exercise prescription and 12 participants served as controls. Cognitive assessments, cardiorespiratory fitness and plasma BDNF and CTHB concentrations were measured at baseline and eight weeks. Results:Results showed exercise improved cardiorespiratory fitness (p = 0.044, d = 1.48) with no improvements in cognitive function or no changes in plasma BDNF and CTHB concentrations. Conclusion:We provide evidence that a short-term course of moderate exercise does not improve cognitive function or change plasma biochemical markers concentrations in young and healthy adults, despite mild improvements in cardiorespiratory fitness. These results suggest that cognitive health may peak during early adulthood leaving little room for improvement throughout this period of the lifespan.

SUBMITTER: Gourgouvelis J

PROVIDER: S-EPMC5911384 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature

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You can't fix what isn't broken: eight weeks of exercise do not substantially change cognitive function and biochemical markers in young and healthy adults.

Gourgouvelis Joanne J Yielder Paul P Clarke Sandra T ST Behbahani Hushyar H Murphy Bernadette B

PeerJ 20180419

<h4>Objective</h4>The benefits of exercise on brain health is well known in aging and psychiatric populations. However, the relationship between habitual exercise in young and healthy adults remains unclear. This study explored the effects an eight-week exercise prescription on cognitive function, brain-derived neurotrophic factor (BDNF) and cathepsin B (CTHB) in young and healthy adults.<h4>Methods</h4>A total of 22 low-active, young and healthy adults were recruited from a local university. A ...[more]

PMID: 29686948

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Project description:Exercise can be both anabolic and catabolic for bone tissue. The temporal response of both bone formation and resorption following an acute bout of exercise is not well described. We assayed biochemical markers of bone and calcium metabolism for up to 3 days after military-relevant exercise. In randomized order, male (n = 18) and female (n = 2) Soldiers (means ± SD; 21.2 ± 4.1 years) performed a 60-min bout of load carriage (30% body mass; 22.4 ± 3.7 kg) treadmill exercise (EXER) or a resting control trial (REST). Blood samples were collected following provision of a standardized breakfast before (PRE), after (POST) exercise/rest, 1 h, 2 h, and 4 h into recovery. Fasted samples were also collected at 0630 on EXER and REST and for the next three mornings after EXER. Parathyroid hormone and phosphorus were elevated (208% and 128% of PRE, respectively, P < 0.05), and ionized calcium reduced (88% of PRE, P < 0.05) after EXER. N-terminal propeptide of type 1 collagen was elevated at POST (111% of PRE, P < 0.05), and the resorption marker, C-terminal propeptide of type 1 collagen was elevated at 1 h (153% of PRE, P < 0.05). Osteocalcin was higher than PRE at 1 through 4 h post EXER (119%-120% of PRE, P < 0.05). Sclerostin and Dickkopf-related protein-1 were elevated only at POST (132% and 121% of PRE, respectively, P < 0.05) during EXER. Trivial changes in biomarkers during successive recovery days were observed. These results suggest that 60 min of load carriage exercise elicits transient increases in bone formation and resorption that return to pre-exercise concentrations within 24 h post-exercise.NEW & NOTEWORTHY In this study, we demonstrated evidence for increases in both bone formation and resorption in the first 4 h after a bout of load carriage exercise. However, these changes largely disappear by 24 h after exercise. Acute formation and resorption of bone following exercise may reflect distinct physiological mechanoadaptive responses. Future work is needed to identify ways to promote acute post-exercise bone formation and minimize post-exercise resorption to optimize bone adaptation to exercise.

Project description:Background:Although the studies of barefoot running have intensified, it is still missing longitudinal work analyzing the effects of barefoot running on the phases of plantar support. The objective of this research was to analyze the modifications undergone by the Total Foot Contact (TFC) phase and its Flat Foot Phase (FFP) in subjects beginning the practice of barefoot running, in its acute and chronic effects. Methods:A total of 28 subjects were divided into the Barefoot Group (BFGr) (n = 16) and the Shod Group (SHGr) (n = 12), evaluated before (Baseline) and after running for 20 min at 3.05 m·s-1 (Post 20 min Running), and at the end of a running training protocol with an 8-week long progressive volume (Post-8-week Training). The dynamic plantar support was measured with a baropodoscope. The duration of TFC (ms), the moment at which the FFP occurred, the maximum surface of TFC (MSTFC) (cm2), the FFP surface (SFFP) (cm2), the peak pressure of TFC (PP°TFC) (kg·cm-2), and the peak pressure of FFP (PP°FFP) (kg·cm-2) were recorded. The 3 × 2 ANOVA analysis was made to determine the effects and interactions that the condition produced (Shod/Barefoot), and the time factor (Baseline/Post 20 min Running/Post-8-week Training). Results:The condition factor caused more significant effects than the time factor in all the variables. Duration of TFC in BFGr showed significant differences between the Baseline and Post-8-week Training (p = 0.000) and between Post-20-min Running and Post-8-week Training (p = 0.000), with an increasing trend. In the moment at which the FFP occurred a significant increase (p = 0.029) increase was found in Post-20 min Running (48.5%) compared to the Baseline (42.9%). In MSTFC, BFGr showed in Post-8-week Training values significantly higher than the Baseline (p = 0.000) and than Post-20-min Running (p = 0.000). SHGr presented a significant difference between the Baseline and Post-8-week Training (p = 0.040). SFFP in BFGr modified its values with an increasing trend (p = 0.000). PP°TFC in BFGr showed a significant decrease (p = 0.003) in Post-8-week Training (1.9 kg·cm-2) compared to the Baseline (2.4 kg·cm-2). In PP°FFP significant decreases were recorded in BFGr and between Post-8-week Training and Baseline (p = 0.000), and Post-8-week Training and Post 20 min Running (p = 0.035). Conclusions:The adaptation took place after the 8-week training. The adaptations to running barefoot were characterized by causing an increase of the foot's plantar support in TFC and in FFP, as well as a decrease of the plantar pressure peak in both phases. Also, there is an increased duration of the TFC and FFP, which may be related to an acquired strategy to attenuate the impacts of the ground's reaction forces.

Dataset Information

You can't fix what isn't broken: eight weeks of exercise do not substantially change cognitive function and biochemical markers in young and healthy adults.

Publications

You can't fix what isn't broken: eight weeks of exercise do not substantially change cognitive function and biochemical markers in young and healthy adults.

Similar Datasets

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