Ontology highlight
ABSTRACT:
SUBMITTER: Pi M
PROVIDER: S-EPMC5912754 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Pi Min M Kapoor Karan K Ye Ruisong R Hwang Dong-Jin DJ Miller Duane D DD Smith Jeremy C JC Baudry Jerome J Quarles L Darryl LD
PloS one 20180423 4
New insights into G protein coupled receptor regulation of glucose metabolism by β-cells, skeletal muscle and liver hepatocytes identify GPRC6A as a potential therapeutic target for treating type 2 diabetes mellitus (T2D). Activating GPRC6A with a small molecule drug represents a potential paradigm-shifting opportunity to make significant strides in regulating glucose homeostasis by simultaneously correcting multiple metabolic derangements that underlie T2D, including abnormalities in β-cell pro ...[more]