Ontology highlight
ABSTRACT:
SUBMITTER: Frayling TM
PROVIDER: S-EPMC5912948 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Cell reports 20180401 2
Fibroblast growth factor 21 (FGF21) is a hormone that has insulin-sensitizing properties. Some trials of FGF21 analogs show weight loss and lipid-lowering effects. Recent studies have shown that a common allele in the FGF21 gene alters the balance of macronutrients consumed, but there was little evidence of an effect on metabolic traits. We studied a common FGF21 allele (A:rs838133) in 451,099 people from the UK Biobank study, aiming to use the human allele to inform potential adverse and benefi ...[more]