Associations between genetic variants associated with body mass index and trajectories of body fatness across the life course: a longitudinal analysis.
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ABSTRACT:
SUBMITTER: Song M
PROVIDER: S-EPMC5913610 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
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Associations between genetic variants associated with body mass index and trajectories of body fatness across the life course: a longitudinal analysis.
Song Mingyang M Zheng Yan Y Qi Lu L Hu Frank B FB Chan Andrew T AT Giovannucci Edward L EL
International journal of epidemiology 20180401 2
<h4>Background</h4>The genetic associations with trajectories of body fatness over the life course remain unknown.<h4>Methods</h4>We used a group-based modelling approach to identify trajectories of body fatness from age 5 years up to 65 for 7277 women from the Nurses' Health Study and 4645 men from the Health Professionals Follow-up Study. We created a genetic risk score (GRS) based on 97 variants associated with adulthood body mass index (BMI) and estimated its association with trajectories us ...[more]
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