Ontology highlight
ABSTRACT:
SUBMITTER: Early JV
PROVIDER: S-EPMC4879361 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Antimicrobial agents and chemotherapy 20160523 6
Mycobacterium tuberculosis is a global pathogen of huge importance which can adapt to several host niche environments in which carbon source availability is likely to vary. We developed and ran a phenotypic screen using butyrate as the sole carbon source to be more reflective of the host lung environment. We screened a library of ∼87,000 small compounds and identified compounds which demonstrated good antitubercular activity against M. tuberculosis grown with butyrate but not with glucose as the ...[more]