Ontology highlight
ABSTRACT:
SUBMITTER: Angelos MG
PROVIDER: S-EPMC5914515 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Angelos Mathew G MG Abrahante Juan E JE Blum Robert H RH Kaufman Dan S DS
Stem cells (Dayton, Ohio) 20171213 2
Endothelial-to-hematopoietic transition (EHT) is an important stage in definitive hematopoietic development. However, the genetic mechanisms underlying human EHT remain poorly characterized. We performed single cell RNA-seq using 55 hemogenic endothelial cells (HECs: CD31<sup>+</sup> CD144<sup>+</sup> CD41<sup>-</sup> CD43<sup>-</sup> CD45<sup>-</sup> CD73<sup>-</sup> RUNX1c<sup>+</sup> ), 47 vascular endothelial cells without hematopoietic potential (non-HE: CD31<sup>+</sup> CD144<sup>+</sup> C ...[more]