Ontology highlight
ABSTRACT:
SUBMITTER: Anjuwon-Foster BR
PROVIDER: S-EPMC5914908 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Anjuwon-Foster Brandon R BR Tamayo Rita R
Gut microbes 20170921 1
Clostridium difficile is a leading cause of nosocomial infections, causing disease that ranges from mild diarrhea to potentially fatal colitis. A variety of surface proteins, including flagella, enable C. difficile colonization of the intestine. Once in the intestine, toxigenic C. difficile secretes two glucosylating toxins, TcdA and TcdB, which elicit inflammation and diarrheal disease symptoms. Regulation of colonization factors and TcdA and TcdB is an intense area of research in C. difficile ...[more]