Clostridium difficile virulence factors: Insights into an anaerobic spore-forming pathogen.
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ABSTRACT:
SUBMITTER: Awad MM
PROVIDER: S-EPMC4615314 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Publications
Clostridium difficile virulence factors: Insights into an anaerobic spore-forming pathogen.
Awad Milena M MM Johanesen Priscilla A PA Carter Glen P GP Rose Edward E Lyras Dena D
Gut microbes 20140101 5
The worldwide emergence of epidemic strains of Clostridium difficile linked to increased disease severity and mortality has resulted in greater research efforts toward determining the virulence factors and pathogenesis mechanisms used by this organism to cause disease. C. difficile is an opportunist pathogen that employs many factors to infect and damage the host, often with devastating consequences. This review will focus on the role of the 2 major virulence factors, toxin A (TcdA) and toxin B ...[more]
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