Biological Insights Into Muscular Strength: Genetic Findings in the UK Biobank.
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ABSTRACT:
SUBMITTER: Tikkanen E
PROVIDER: S-EPMC5915424 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Publications
Biological Insights Into Muscular Strength: Genetic Findings in the UK Biobank.
Tikkanen Emmi E Gustafsson Stefan S Amar David D Shcherbina Anna A Waggott Daryl D Ashley Euan A EA Ingelsson Erik E
Scientific reports 20180424 1
We performed a large genome-wide association study to discover genetic variation associated with muscular strength, and to evaluate shared genetic aetiology with and causal effects of muscular strength on several health indicators. In our discovery analysis of 223,315 individuals, we identified 101 loci associated with grip strength (P <5 × 10<sup>-8</sup>). Of these, 64 were associated (P < 0.01 and consistent direction) also in the replication dataset (N = 111,610). eQTL analyses highlighted s ...[more]
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