Ontology highlight
ABSTRACT:
SUBMITTER: Cheng W
PROVIDER: S-EPMC5915597 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Translational psychiatry 20180425 1
To analyze the functioning of the posterior cingulate cortex (PCC) in depression, we performed the first fully voxel-level resting state functional-connectivity neuroimaging analysis of depression of the PCC, with 336 patients with major depressive disorder and 350 controls. Voxels in the PCC had significantly increased functional connectivity with the lateral orbitofrontal cortex, a region implicated in non-reward and which is thereby implicated in depression. In patients receiving medication, ...[more]