Apremilast Alters Behavioral Responses to Ethanol in Mice: I. Reduced Consumption and Preference.

ABSTRACT:

Background

Phosphodiesterase type 4 (PDE4) inhibitors produce widespread anti-inflammatory effects and reduce ethanol (EtOH) consumption in several rodent models. These drugs are potential treatments for several diseases, including central nervous system disorders, but clinical use is limited by their emetic activity. Apremilast is a selective PDE4 inhibitor with fewer gastrointestinal side effects that is FDA-approved for the treatment of psoriasis.

Methods

We measured the acute and chronic effects of apremilast on EtOH consumption in male and female C57BL/6J mice using the continuous and intermittent 24-hour 2-bottle choice drinking models. We also studied the effects of apremilast on preference for sucrose or saccharin, spontaneous locomotor activity, and blood EtOH clear

SUBMITTER: Blednov YA 

PROVIDER: S-EPMC5915912 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature