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Clinical Implications of Pediatric Colonic Eosinophilia.

ABSTRACT: OBJECTIVE:Pediatric colonic eosinophilia represents a confounding finding with a wide differential. It is often difficult to determine which children may progress to inflammatory bowel disease (IBD), which have an eosinophilic colitis (EC), and which may have no underlying pathology. There is little guidance for the practitioner on the approach to these patients. To define the clinical presentations of colonic eosinophilia and identify factors which may aid in diagnosis we reviewed patients with colonic eosinophilia and the clinicopathologic factors associated with their diagnoses. METHODS:An 8-year retrospective chart review of children whose histopathology identified colonic eosinophilia (N?=?72) compared to controls with normal biopsies (N?=?35). RESULTS:Patients with colonic eosinophilia had increased eosinophils/high-power field compared to controls (P?1 colonoscopy and 68% of these had change from initial diagnoses. CONCLUSIONS:There are 3 main phenotypes of children with colonic eosinophilia. Signs of chronic systemic inflammation raise suspicion for IBD. Peripheral eosinophilia and male sex are associated with EC. A significant percent of children with colonic eosinophilia do not have colonic disease. Eosinophils/high-power field is not reliable to differentiate etiologies. Repeat colonoscopies may be required to reach final diagnoses.

SUBMITTER: Mark J

PROVIDER: S-EPMC5916023 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature

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Clinical Implications of Pediatric Colonic Eosinophilia.

Mark Jacob J Fernando Shahan D SD Masterson Joanne C JC Pan Zhaoxing Z Capocelli Kelley E KE Furuta Glenn T GT de Zoeten Edwin F EF

Journal of pediatric gastroenterology and nutrition 20180501 5

<h4>Objective</h4>Pediatric colonic eosinophilia represents a confounding finding with a wide differential. It is often difficult to determine which children may progress to inflammatory bowel disease (IBD), which have an eosinophilic colitis (EC), and which may have no underlying pathology. There is little guidance for the practitioner on the approach to these patients. To define the clinical presentations of colonic eosinophilia and identify factors which may aid in diagnosis we reviewed patie ...[more]

PMID: 29095349

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Project description:BackgroundThe pathology of pediatric severe therapy-resistant asthma (STRA) is little understood.ObjectivesWe hypothesized that STRA in children is characterized by airway eosinophilia and mast cell inflammation and is driven by the T(H)2 cytokines IL-4, IL-5, and IL-13.MethodsSixty-nine children (mean age, 11.8 years; interquartile range, 5.6-17.3 years; patients with STRA, n = 53; control subjects, n = 16) underwent fiberoptic bronchoscopy, bronchoalveolar lavage (BAL), and endobronchial biopsy. Airway inflammation, remodeling, and BAL fluid and biopsy specimen T(H)2 cytokines were quantified. Children with STRA also underwent symptom assessment (Asthma Control Test), spirometry, exhaled nitric oxide and induced sputum evaluation.ResultsChildren with STRA had significantly increased BAL fluid and biopsy specimen eosinophil counts compared with those found in control subjects (BAL fluid, P < .001; biopsy specimen, P < .01); within the STRA group, there was marked between-patient variability in eosinophilia. Submucosal mast cell, neutrophil, and lymphocyte counts were similar in both groups. Reticular basement membrane thickness and airway smooth muscle were increased in patients with STRA compared with those found in control subjects (P < .0001 and P < .001, respectively). There was no increase in BAL fluid IL-4, IL-5, or IL-13 levels in patients with STRA compared with control subjects, and these cytokines were rarely detected in induced sputum. Biopsy IL-5(+) and IL-13(+) cell counts were also not higher in patients with STRA compared with those seen in control subjects. The subgroup (n = 15) of children with STRA with detectable BAL fluid T(H)2 cytokines had significantly lower lung function than those with undetectable BAL fluid T(H)2 cytokines.ConclusionsSTRA in children was characterized by remodeling and variable airway eosinophil counts. However, unlike in adults, there was no neutrophilia, and despite the wide range in eosinophil counts, the T(H)2 mediators that are thought to drive allergic asthma were mostly absent.

Dataset Information

Clinical Implications of Pediatric Colonic Eosinophilia.

Publications

Clinical Implications of Pediatric Colonic Eosinophilia.

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