Ontology highlight
ABSTRACT:
SUBMITTER: Patel D
PROVIDER: S-EPMC5916510 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Patel Dharmesh D Sharma Sadhana S Screen Hazel R C HRC Bryant Stephanie J SJ
Biochemical and biophysical research communications 20180402 3
We recently developed a fiber composite consisting of tenocytes seeded onto discontinuous fibers embedded within a hydrogel, designed to mimic physiological tendon micromechanics of tension and shear. This study examined if cell adhesion peptide (DGEA or YRGDS), fiber modulus (50 or 1300 kPa) and/or cyclic strain (5% strain, 1 Hz) influenced bovine tenocyte gene expression. Ten genes were analyzed and none were sensitive to peptide or fiber modulus in the absence of cyclic tensile strain. Genes ...[more]