Ontology highlight
ABSTRACT:
SUBMITTER: Stepanova LA
PROVIDER: S-EPMC5916737 | biostudies-literature | 2018 Jan-Mar
REPOSITORIES: biostudies-literature
Stepanova L A LA Kotlyarov R Y RY Shuklina M A MA Blochina E A EA Sergeeva M V MV Potapchuk M V MV Kovaleva A A AA Ravin N V NV Tsybalova L M LM
Acta naturae 20180101 1
The ectodomain of the M2 protein (M2e) and the conserved fragment of the second subunit of hemagglutinin (HA2) are promising candidates for broadly protective vaccines. In this paper, we report on the design of chimeric constructs with differing orders of linkage of four tandem copies of M2e and the conserved fragment of HA2 (76-130) from phylogenetic group II influenza A viruses to the C-terminus of flagellin. The 3D-structure of two chimeric proteins showed that interior location of the M2e ta ...[more]