Ontology highlight
ABSTRACT:
SUBMITTER: Imaizumi K
PROVIDER: S-EPMC5917473 | biostudies-literature | 2018 Mar-Apr
REPOSITORIES: biostudies-literature
Imaizumi Kent K Fujimori Koki K Ishii Seiji S Otomo Asako A Hosoi Yasushi Y Miyajima Hiroaki H Warita Hitoshi H Aoki Masashi M Hadano Shinji S Akamatsu Wado W Okano Hideyuki H
eNeuro 20180301 2
The cerebral cortex is subdivided into distinct areas that have particular functions. The rostrocaudal (R-C) gradient of fibroblast growth factor 8 (FGF8) signaling defines this areal identity during neural development. In this study, we recapitulated cortical R-C patterning in human pluripotent stem cell (PSC) cultures. Modulation of FGF8 signaling appropriately regulated the R-C markers, and the patterns of global gene expression resembled those of the corresponding areas of human fetal brains ...[more]