Ontology highlight
ABSTRACT:
SUBMITTER: Seth M
PROVIDER: S-EPMC5918280 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Seth Meetu M Shirayama Masaki M Tang Wen W Shen En-Zhi EZ Tu Shikui S Lee Heng-Chi HC Weng Zhiping Z Mello Craig C CC
Cell reports 20180215 9
Protein-coding genes undergo a wide array of regulatory interactions with factors that engage non-coding regions. Open reading frames (ORFs), in contrast, are thought to be constrained by coding function, precluding a major role in gene regulation. Here, we explore Piwi-interacting (pi)RNA-mediated transgene silencing in C. elegans and show that marked differences in the sensitivity to piRNA silencing map to the endogenous sequences within transgene ORFs. Artificially increasing piRNA targeting ...[more]