Ontology highlight
ABSTRACT:
SUBMITTER: Aminzadeh MA
PROVIDER: S-EPMC5918344 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Aminzadeh Mark A MA Rogers Russell G RG Fournier Mario M Tobin Rachel E RE Guan Xuan X Childers Martin K MK Andres Allen M AM Taylor David J DJ Ibrahim Ahmed A Ding Xiangming X Torrente Angelo A Goldhaber Joshua M JM Lewis Michael M Gottlieb Roberta A RA Victor Ronald A RA Marbán Eduardo E
Stem cell reports 20180301 3
Genetic deficiency of dystrophin leads to disability and premature death in Duchenne muscular dystrophy (DMD), affecting the heart as well as skeletal muscle. Here, we report that clinical-stage cardiac progenitor cells, known as cardiosphere-derived cells (CDCs), improve cardiac and skeletal myopathy in the mdx mouse model of DMD. Injection of CDCs into the hearts of mdx mice augments cardiac function, ambulatory capacity, and survival. Exosomes secreted by human CDCs reproduce the benefits of ...[more]