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Effect of Protein Supplementation During Diet-Induced Weight Loss on Muscle Mass and Strength: A Randomized Controlled Study.


ABSTRACT: OBJECTIVE:High protein (particularly leucine-rich whey protein) intake is recommended to mitigate the adverse effect of weight loss on muscle mass. The effectiveness of this approach is unknown. METHODS:Seventy middle-aged (50-65 years old) postmenopausal women with obesity were randomized to (1) weight maintenance (WM), (2) weight loss and the recommended daily allowance for protein (0.8 g/kg/d) (WL group), or (3) weight loss plus whey protein supplementation (total protein: 1.2?g/kg/d) (WL-PS group). Thigh muscle volume and strength were assessed at baseline and after 5% and 10% weight loss in the weight-loss groups and after matched time periods (?3 and 6 months, respectively) in the WM group. RESULTS:A 5% weight loss caused a greater decrease in thigh muscle volume in the WL group than the WL-PS group (4.7%?±?0.7% vs. 2.8%?±?0.8%, respectively; P?

SUBMITTER: Smith GI 

PROVIDER: S-EPMC5918424 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature

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Effect of Protein Supplementation During Diet-Induced Weight Loss on Muscle Mass and Strength: A Randomized Controlled Study.

Smith Gordon I GI   Commean Paul K PK   Reeds Dominic N DN   Klein Samuel S   Mittendorfer Bettina B  

Obesity (Silver Spring, Md.) 20180501 5


<h4>Objective</h4>High protein (particularly leucine-rich whey protein) intake is recommended to mitigate the adverse effect of weight loss on muscle mass. The effectiveness of this approach is unknown.<h4>Methods</h4>Seventy middle-aged (50-65 years old) postmenopausal women with obesity were randomized to (1) weight maintenance (WM), (2) weight loss and the recommended daily allowance for protein (0.8 g/kg/d) (WL group), or (3) weight loss plus whey protein supplementation (total protein: 1.2   ...[more]

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