Ontology highlight
ABSTRACT:
SUBMITTER: Young JE
PROVIDER: S-EPMC5919412 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Young Jessica E JE Fong Lauren K LK Frankowski Harald H Petsko Gregory A GA Small Scott A SA Goldstein Lawrence S B LSB
Stem cell reports 20180301 3
Developing effective therapeutics for complex diseases such as late-onset, sporadic Alzheimer's disease (SAD) is difficult due to genetic and environmental heterogeneity in the human population and the limitations of existing animal models. Here, we used hiPSC-derived neurons to test a compound that stabilizes the retromer, a highly conserved multiprotein assembly that plays a pivotal role in trafficking molecules through the endosomal network. Using this human-specific system, we have confirmed ...[more]