Ontology highlight
ABSTRACT:
SUBMITTER: Mischo HE
PROVIDER: S-EPMC5919780 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Mischo Hannah E HE Chun Yujin Y Harlen Kevin M KM Smalec Brendan M BM Dhir Somdutta S Churchman L Stirling LS Buratowski Stephen S
Molecular cell 20180412 2
Many non-coding transcripts (ncRNA) generated by RNA polymerase II in S. cerevisiae are terminated by the Nrd1-Nab3-Sen1 complex. However, Sen1 helicase levels are surprisingly low compared with Nrd1 and Nab3, raising questions regarding how ncRNA can be terminated in an efficient and timely manner. We show that Sen1 levels increase during the S and G2 phases of the cell cycle, leading to increased termination activity of NNS. Overexpression of Sen1 or failure to modulate its abundance by ubiqui ...[more]