Ontology highlight
ABSTRACT:
SUBMITTER: Scheunemann L
PROVIDER: S-EPMC5919781 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Scheunemann Lisa L Plaçais Pierre-Yves PY Dromard Yann Y Schwärzel Martin M Preat Thomas T
Neuron 20180401 2
A key function of the brain is to filter essential information and store it in the form of stable, long-term memory (LTM). We demonstrate here that the Dunce (Dnc) phosphodiesterase, an important enzyme that degrades cAMP, acts as a molecular switch that controls LTM formation in Drosophila. We show that, during LTM formation, Dnc is inhibited in the SPN, a pair of newly characterized serotonergic neurons, which stimulates the cAMP/PKA pathway. As a consequence, the SPN activates downstream dopa ...[more]