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Surface receptor Toso controls B cell-mediated regulation of T cell immunity.


ABSTRACT: The immune system is tightly controlled by regulatory processes that allow for the elimination of invading pathogens, while limiting immunopathological damage to the host. In the present study, we found that conditional deletion of the cell surface receptor Toso on B cells unexpectedly resulted in impaired proinflammatory T cell responses, which led to impaired immune protection in an acute viral infection model and was associated with reduced immunopathological tissue damage in a chronic inflammatory context. Toso exhibited its B cell-inherent immunoregulatory function by negatively controlling the pool of IL-10-competent B1 and B2 B cells, which were characterized by a high degree of self-reactivity and were shown to mediate immunosuppressive activity on inflammatory T cell responses in vivo. Our results indicate that Toso is involved in the differentiation/maintenance of regulatory B cells by fine-tuning B cell receptor activation thresholds. Furthermore, we showed that during influenza A-induced pulmonary inflammation, the application of Toso-specific antibodies selectively induced IL-10-competent B cells at the site of inflammation and resulted in decreased proinflammatory cytokine production by lung T cells. These findings suggest that Toso may serve as a novel therapeutic target to dampen pathogenic T cell responses via the modulation of IL-10-competent regulatory B cells.

SUBMITTER: Yu J 

PROVIDER: S-EPMC5919877 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature

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Surface receptor Toso controls B cell-mediated regulation of T cell immunity.

Yu Jinbo J   Duong Vu Huy Hoang VHH   Westphal Katrin K   Westphal Andreas A   Suwandi Abdulhadi A   Grassl Guntram A GA   Brand Korbinian K   Chan Andrew C AC   Föger Niko N   Lee Kyeong-Hee KH  

The Journal of clinical investigation 20180403 5


The immune system is tightly controlled by regulatory processes that allow for the elimination of invading pathogens, while limiting immunopathological damage to the host. In the present study, we found that conditional deletion of the cell surface receptor Toso on B cells unexpectedly resulted in impaired proinflammatory T cell responses, which led to impaired immune protection in an acute viral infection model and was associated with reduced immunopathological tissue damage in a chronic inflam  ...[more]

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