Ontology highlight
ABSTRACT:
SUBMITTER: Yu J
PROVIDER: S-EPMC5919877 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Yu Jinbo J Duong Vu Huy Hoang VHH Westphal Katrin K Westphal Andreas A Suwandi Abdulhadi A Grassl Guntram A GA Brand Korbinian K Chan Andrew C AC Föger Niko N Lee Kyeong-Hee KH
The Journal of clinical investigation 20180403 5
The immune system is tightly controlled by regulatory processes that allow for the elimination of invading pathogens, while limiting immunopathological damage to the host. In the present study, we found that conditional deletion of the cell surface receptor Toso on B cells unexpectedly resulted in impaired proinflammatory T cell responses, which led to impaired immune protection in an acute viral infection model and was associated with reduced immunopathological tissue damage in a chronic inflam ...[more]