ABO Antigens Active Tri- and Disaccharides Microarray to Evaluate C-type Lectin Receptor Binding Preferences.
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ABSTRACT:
SUBMITTER: Shanthamurthy CD
PROVIDER: S-EPMC5920051 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
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ABO Antigens Active Tri- and Disaccharides Microarray to Evaluate C-type Lectin Receptor Binding Preferences.
Shanthamurthy Chethan D CD Jain Prashant P Yehuda Sharon S Monteiro João T JT Leviatan Ben-Arye Shani S Subramani Balamurugan B Lepenies Bernd B Padler-Karavani Vered V Kikkeri Raghavendra R
Scientific reports 20180426 1
Understanding blood group antigen binding preferences for C-type lectin receptors holds promise for modulating immune responses, since several Gram-negative bacteria express blood group antigens as molecular mimicry to evade immune responses. Herein, we report the synthesis of ABO blood group antigen active tri and disaccharides to investigate the binding specificity with various C-type lectin receptors using glycan microarray. The results of binding preferences show that distinct glycosylation ...[more]
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