Ontology highlight
ABSTRACT:
SUBMITTER: Ren X
PROVIDER: S-EPMC5920373 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Ren Xiaolei X Tu Chao C Tang Zhenchu Z Ma Ruofei R Li Zhihong Z
Oncology letters 20180322 5
Sarcoma is a rare and heterogeneous type of cancer with an early mean onset age and a poor prognosis. However, its genetic basis remains unclear. A series of recent genomic studies in sarcomas have identified the occurrence of mutations in the α-thalassemia/mental retardation syndrome X-linked (ATRX) gene. The ATRX protein belongs to the SWI/SNF family of chromatin remodeling proteins, which are frequently associated with α-thalassemia syndrome. Cancer cells depend on telomerase or the alternati ...[more]