Ontology highlight
ABSTRACT:
SUBMITTER: Hetrick KJ
PROVIDER: S-EPMC5920614 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Hetrick Kenton J KJ Walker Mark C MC van der Donk Wilfred A WA
ACS central science 20180328 4
Peptide display has enabled identification and optimization of ligands to many targets. These ligands are usually linear or disulfide-containing peptides that are vulnerable to proteolysis or reduction. We report yeast surface and phage display of lanthipeptides, macrocyclic ribosomally synthesized and post-translationally modified peptides (RiPPs). Lanthipeptides contain multiple thioether cross-links that bestow their biological activities. We developed C-terminal yeast display of the class II ...[more]