Ontology highlight
ABSTRACT:
SUBMITTER: Urban JH
PROVIDER: S-EPMC5686179 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Urban Johannes H JH Moosmeier Markus A MA Aumüller Tobias T Thein Marcus M Bosma Tjibbe T Rink Rick R Groth Katharina K Zulley Moritz M Siegers Katja K Tissot Kathrin K Moll Gert N GN Prassler Josef J
Nature communications 20171115 1
Ribosomally synthesized and post-translationally modified peptides (RiPPs) are an emerging class of natural products with drug-like properties. To fully exploit the potential of RiPPs as peptide drug candidates, tools for their systematic engineering are required. Here we report the engineering of lanthipeptides, a subclass of RiPPs characterized by multiple thioether cycles that are enzymatically introduced in a regio- and stereospecific manner, by phage display. This was achieved by heterologo ...[more]