The effects of short-term fasting on quality of life and tolerance to chemotherapy in patients with breast and ovarian cancer: a randomized cross-over pilot study.

ABSTRACT: BACKGROUND:This pilot trial aimed to study the feasibility and effects on quality of life (QOL) and well-being of short-term fasting (STF) during chemotherapy in patients with gynecological cancer. METHODS:In an individually-randomized cross-over trial patients with gynecological cancer, 4 to 6 planned chemotherapy cycles were included. Thirty-four patients were randomized to STF in the first half of chemotherapies followed by normocaloric diet (group A;n =?18) or vice versa (group B;n =?16). Fasting started 36 h before and ended 24 h after chemotherapy (60 h-fasting period). QOL was assessed by the FACIT-measurement system. RESULTS:The chemotherapy-induced reduction of QOL was less than the Minimally Important Difference (MID; FACT-G?=?5) with STF but greater than the MID for non-fasted periods. The mean chemotherapy-induced deterioration of total FACIT-F was 10.4?±?5.3 for fasted and 27.0?±?6.3 for non-fasted cycles in group A and 14.1?±?5.6 for non-fasted and 11.0?±?5.6 for fasted cycles in group B. There were no serious adverse effects. CONCLUSION:STF during chemotherapy is well tolerated and appears to improve QOL and fatigue during chemotherapy. Larger studies should prove the effect of STF as an adjunct to chemotherapy. TRIAL REGISTRATION:This trial was registered at clinicaltrials.gov: NCT01954836 .

SUBMITTER: Bauersfeld SP 

PROVIDER: S-EPMC5921787 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature