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Coexistence of Two blaNDM-5 Genes on an IncF Plasmid as Revealed by Nanopore Sequencing.

ABSTRACT: In a carbapenem-resistant Escherichia coli clinical isolate of sequence type 167, two copies of blaNDM-5 were found on a 144,225-bp IncF self-transmissible plasmid of the F36:A4:B- type. Both blaNDM-5 genes were located in 11,065-bp regions flanked by two copies of IS26 The two regions were identical in sequence but were present at different locations on the plasmid, suggesting a duplication of the same region. This study highlights the complex genetic contexts of blaNDM-5.

SUBMITTER: Feng Y 

PROVIDER: S-EPMC5923099 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature

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Coexistence of Two <i>bla</i><sub>NDM-5</sub> Genes on an IncF Plasmid as Revealed by Nanopore Sequencing.

Feng Yu Y   Liu Lu L   McNally Alan A   Zong Zhiyong Z  

Antimicrobial agents and chemotherapy 20180426 5

In a carbapenem-resistant <i>Escherichia coli</i> clinical isolate of sequence type 167, two copies of <i>bla</i><sub>NDM-5</sub> were found on a 144,225-bp IncF self-transmissible plasmid of the F36:A4:B<sup>-</sup> type. Both <i>bla</i><sub>NDM-5</sub> genes were located in 11,065-bp regions flanked by two copies of IS<i>26</i> The two regions were identical in sequence but were present at different locations on the plasmid, suggesting a duplication of the same region. This study highlights th  ...[more]

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