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Emergence of NDM-5-Producing Escherichia coli in a Teaching Hospital in Chongqing, China: IncF-Type Plasmids May Contribute to the Prevalence of bla NDM- 5.


ABSTRACT: The newly emerging NDM-5 confers increased antibiotic resistance and attracts extensive global attention, but the prevalence, dissemination mechanism, and clinical significance of NDM-5 among clinical Escherichia coli (E. coli) infections have not been thoroughly characterized to date. In the present study, 109 unique carbapenem-resistant E. coli (CR-EC) isolates were collected in Southwest China, from 2013 to 2017, among which 41 (37.61%) CR-EC isolates were identified as NDM-5-producers, with most isolates carrying the IncF-type plasmids. Molecular epidemiological studies revealed ST167 being the most common sequence type (ST). Moreover, we described the first report of a clinical CR-EC isolate co-harboring bla KPC- 2 and bla NDM- 5, which showed a higher level of resistance to carbapenems. In addition, bla NDM- 5 plasmid transformation and conjugation indicated that bla NDM- 5 itself did confer resistance to carbapenems. Complete sequencing of the bla NDM- 5-harboring IncF plasmid revealed highly conserved regions (ble MBL-trpF-tat) and some transposons around bla NDM- 5. Our findings revealed a new potential threat of NDM-5-postive CR-EC in mainland China and emphasized an urgent need to control their further spread.

SUBMITTER: Zou H 

PROVIDER: S-EPMC7069339 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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Emergence of NDM-5-Producing <i>Escherichia coli</i> in a Teaching Hospital in Chongqing, China: IncF-Type Plasmids May Contribute to the Prevalence of <i>bla</i> <sub>NDM-</sub> <sub>5</sub>.

Zou Hua H   Jia Xiaojiong X   Liu Hang H   Li Shuang S   Wu Xianan X   Huang Shifeng S  

Frontiers in microbiology 20200306


The newly emerging NDM-5 confers increased antibiotic resistance and attracts extensive global attention, but the prevalence, dissemination mechanism, and clinical significance of NDM-5 among clinical <i>Escherichia coli</i> (<i>E. coli</i>) infections have not been thoroughly characterized to date. In the present study, 109 unique carbapenem-resistant <i>E. coli</i> (CR-EC) isolates were collected in Southwest China, from 2013 to 2017, among which 41 (37.61%) CR-EC isolates were identified as N  ...[more]

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