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Marine Longilenes, Oxasqualenoids with Ser-Thr Protein Phosphatase 2A Inhibition Activity.


ABSTRACT: The red seaweed Laurencia viridis is a rich source of oxygenated secondary metabolites that were derived from squalene. We report here the structures of three novel compounds, (+)-longilene peroxide (1), longilene (2), and (+)-prelongilene (3) that were isolated from this alga, in addition to other substances, 4 and 5, resulting from their acid-mediated degradation. The effect of compounds 1 and 3 against Ser-Thr protein phosphatase type 2A (PP2A) was evaluated, showing that (+)-longilene peroxide (1) inhibited PP2A (IC50 11.3 μM). In order to explain the interaction between PP2A and compounds 1 and 3, molecular docking simulations onto the PP2A enzyme-binding region were used.

SUBMITTER: Cen-Pacheco F 

PROVIDER: S-EPMC5923418 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature

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Marine Longilenes, Oxasqualenoids with Ser-Thr Protein Phosphatase 2A Inhibition Activity.

Cen-Pacheco Francisco F   Pérez Manríquez Claudia C   Luisa Souto María M   Norte Manuel M   Fernández José Javier JJ   Hernández Daranas Antonio A  

Marine drugs 20180417 4


The red seaweed <i>Laurencia viridis</i> is a rich source of oxygenated secondary metabolites that were derived from squalene. We report here the structures of three novel compounds, (+)-longilene peroxide (<b>1</b>), longilene (<b>2</b>), and (+)-prelongilene (<b>3</b>) that were isolated from this alga, in addition to other substances, <b>4</b> and <b>5</b>, resulting from their acid-mediated degradation. The effect of compounds <b>1</b> and <b>3</b> against Ser-Thr protein phosphatase type 2A  ...[more]

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