Ontology highlight
ABSTRACT:
SUBMITTER: Kamada R
PROVIDER: S-EPMC6392468 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Kamada Rui R Kimura Nozomi N Yoshimura Fumihiko F Tanino Keiji K Sakaguchi Kazuyasu K
PloS one 20190227 2
Obesity is a worldwide public health problem, which is associated with various severe diseases including diabetes, hypertension, atherosclerosis, and cancer. Recent studies have revealed that combination treatment of several different compounds using low doses is effective to reduce side effects. Thus, there is a need to develop an efficient inhibitor for reducing lipid droplets with a divergent target/pathway. Ser/Thr protein phosphatase PPM1D is involved in cellular metabolic processes and is ...[more]