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Diurnal transcriptome atlas of a primate across major neural and peripheral tissues.


ABSTRACT: Diurnal gene expression patterns underlie time-of-the-day-specific functional specialization of tissues. However, available circadian gene expression atlases of a few organs are largely from nocturnal vertebrates. We report the diurnal transcriptome of 64 tissues, including 22 brain regions, sampled every 2 hours over 24 hours, from the primate Papio anubis (baboon). Genomic transcription was highly rhythmic, with up to 81.7% of protein-coding genes showing daily rhythms in expression. In addition to tissue-specific gene expression, the rhythmic transcriptome imparts another layer of functional specialization. Most ubiquitously expressed genes that participate in essential cellular functions exhibit rhythmic expression in a tissue-specific manner. The peak phases of rhythmic gene expression clustered around dawn and dusk, with a "quiescent period" during early night. Our findings also unveil a different temporal organization of central and peripheral tissues between diurnal and nocturnal animals.

SUBMITTER: Mure LS 

PROVIDER: S-EPMC5924732 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature

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Diurnal transcriptome atlas of a primate across major neural and peripheral tissues.

Mure Ludovic S LS   Le Hiep D HD   Benegiamo Giorgia G   Chang Max W MW   Rios Luis L   Jillani Ngalla N   Ngotho Maina M   Kariuki Thomas T   Dkhissi-Benyahya Ouria O   Cooper Howard M HM   Panda Satchidananda S  

Science (New York, N.Y.) 20180208 6381


Diurnal gene expression patterns underlie time-of-the-day-specific functional specialization of tissues. However, available circadian gene expression atlases of a few organs are largely from nocturnal vertebrates. We report the diurnal transcriptome of 64 tissues, including 22 brain regions, sampled every 2 hours over 24 hours, from the primate <i>Papio anubis</i> (baboon). Genomic transcription was highly rhythmic, with up to 81.7% of protein-coding genes showing daily rhythms in expression. In  ...[more]

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