Ontology highlight
ABSTRACT:
SUBMITTER: Zhang L
PROVIDER: S-EPMC5924794 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Zhang Ling L Zhang Li L Liu Huixiang H Jiang Feng F Wang Huanjing H Li Di D Gao Rong R
Frontiers in neuroscience 20180423
Traumatic brain injury (TBI) is a major cause of mortality and disability worldwide. TBI-induced neuronal apoptosis is one of the main contributors to the secondary injury process. The aim of this study is to investigate the involvement of Exchange protein directly activated by cAMP 2 (Epac2) on TBI. We found that the expression level of Epac2 surrounding the injured area of brain in rats of TBI model was significantly increased at 12 h after TBI. The role of Epac2 in TBI was further explored by ...[more]