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Inhibition of Lats1/p-YAP1 pathway mitigates neuronal apoptosis and neurological deficits in a rat model of traumatic brain injury.

ABSTRACT:

Aims

To investigate the roles of Lats1/p-YAP1 pathway in TBI-induced neuronal apoptosis and neurological deficits in rats.

Results

We found that Lats1 and YAP1 were expressed in cerebral cortex neurons of Sprague-Dawley rats, and the phosphorylation levels of Lats1 and YAP1 in injured regions were significantly increased after TBI. Furthermore, inhibition of Lats1 not only decreased the level of p-YAP1, but also attenuated neuronal apoptosis and neurological impairment.

Conclusions

Our work demonstrates that inhibition of Lats1/p-YAP1 pathway mitigates neuronal apoptosis and neurological deficits in a rat model of TBI.

SUBMITTER: Li D

PROVIDER: S-EPMC6489728 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature

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Inhibition of Lats1/p-YAP1 pathway mitigates neuronal apoptosis and neurological deficits in a rat model of traumatic brain injury.

Li Di D Ji Jia-Xuan JX Xu Yi-Tian YT Ni Hai-Bo HB Rui Qin Q Liu Hui-Xiang HX Jiang Feng F Gao Rong R Chen Gang G

CNS neuroscience & therapeutics 20180227 10

<h4>Aims</h4>To investigate the roles of Lats1/p-YAP1 pathway in TBI-induced neuronal apoptosis and neurological deficits in rats.<h4>Results</h4>We found that Lats1 and YAP1 were expressed in cerebral cortex neurons of Sprague-Dawley rats, and the phosphorylation levels of Lats1 and YAP1 in injured regions were significantly increased after TBI. Furthermore, inhibition of Lats1 not only decreased the level of p-YAP1, but also attenuated neuronal apoptosis and neurological impairment.<h4>Conclus ...[more]

PMID: 29488331

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