Antibody Engineering for Optimized Immunotherapy in Alzheimer's Disease.
Ontology highlight
ABSTRACT:
SUBMITTER: Sumner IL
PROVIDER: S-EPMC5924811 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Publications
Antibody Engineering for Optimized Immunotherapy in Alzheimer's Disease.
Sumner Isabelle L IL Edwards Ross A RA Asuni Ayodeji A AA Teeling Jessica L JL
Frontiers in neuroscience 20180423
There are nearly 50 million people with Alzheimer's disease (AD) worldwide and currently no disease modifying treatment is available. AD is characterized by deposits of Amyloid-β (Aβ), neurofibrillary tangles, and neuroinflammation, and several drug discovery programmes studies have focussed on Aβ as therapeutic target. Active immunization and passive immunization against Aβ leads to the clearance of deposits in humans and transgenic mice expressing human Aβ but have failed to improve memory los ...[more]
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