Ontology highlight
ABSTRACT:
SUBMITTER: Orabona C
PROVIDER: S-EPMC5926942 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Orabona Ciriana C Mondanelli Giada G Pallotta Maria T MT Carvalho Agostinho A Albini Elisa E Fallarino Francesca F Vacca Carmine C Volpi Claudia C Belladonna Maria L ML Berioli Maria G MG Ceccarini Giulia G Esposito Susanna Mr SM Scattoni Raffaella R Verrotti Alberto A Ferretti Alessandra A De Giorgi Giovanni G Toni Sonia S Cappa Marco M Matteoli Maria C MC Bianchi Roberta R Matino Davide D Iacono Alberta A Puccetti Matteo M Cunha Cristina C Bicciato Silvio S Antognelli Cinzia C Talesa Vincenzo N VN Chatenoud Lucienne L Fuchs Dietmar D Pilotte Luc L Van den Eynde Benoît B Lemos Manuel C MC Romani Luigina L Puccetti Paolo P Grohmann Ursula U
JCI insight 20180322 6
A defect in indoleamine 2,3-dioxygenase 1 (IDO1), which is responsible for immunoregulatory tryptophan catabolism, impairs development of immune tolerance to autoantigens in NOD mice, a model for human autoimmune type 1 diabetes (T1D). Whether IDO1 function is also defective in T1D is still unknown. We investigated IDO1 function in sera and peripheral blood mononuclear cells (PBMCs) from children with T1D and matched controls. These children were further included in a discovery study to identify ...[more]