Ontology highlight
ABSTRACT:
SUBMITTER: Lozoya OA
PROVIDER: S-EPMC5927466 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Lozoya Oswaldo A OA Martinez-Reyes Inmaculada I Wang Tianyuan T Grenet Dagoberto D Bushel Pierre P Li Jianying J Chandel Navdeep N Woychik Richard P RP Santos Janine H JH
PLoS biology 20180418 4
Mitochondrial function affects many aspects of cellular physiology, and, most recently, its role in epigenetics has been reported. Mechanistically, how mitochondrial function alters DNA methylation patterns in the nucleus remains ill defined. Using a cell culture model of induced mitochondrial DNA (mtDNA) depletion, in this study we show that progressive mitochondrial dysfunction leads to an early transcriptional and metabolic program centered on the metabolism of various amino acids, including ...[more]