Ontology highlight
ABSTRACT:
SUBMITTER: Cortini R
PROVIDER: S-EPMC5928121 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Cortini Ruggero R Filion Guillaume J GJ
Nature communications 20180430 1
All organisms regulate transcription of their genes. To understand this process, a complete understanding of how transcription factors find their targets in cellular nuclei is essential. The DNA sequence and other variables are known to influence this binding, but the distribution of transcription factor binding patterns remains mostly unexplained in metazoan genomes. Here, we investigate the role of chromosome conformation in the trajectories of transcription factors. Using molecular dynamics s ...[more]