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Role of I?B kinase ? in regulating the remodeling of the CARMA1-Bcl10-MALT1 complex.

ABSTRACT: The current work investigates the notion that inducible clustering of signaling mediators of the IKK pathway is important for platelet activation. Thus, while the CARMA1, Bcl10, and MALT1 (CBM) complex is essential for triggering IKK/NF-?B activation upon platelet stimulation, the signals that elicit its formation and downstream effector activation remain elusive. We demonstrate herein that IKK? is involved in membrane fusion, and serves as a critical protein kinase required for initial formation and the regulation of the CARMA1/MALT1/Bcl10/CBM complex in platelets. We also show that IKK? regulates these processes via modulation of phosphorylation of Bcl10 and IKK? polyubiquitination. Collectively, our data demonstrate that IKK? regulates membrane fusion and the remodeling of the CBM complex formation.

SUBMITTER: Karim ZA

PROVIDER: S-EPMC5928781 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature

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Role of IκB kinase β in regulating the remodeling of the CARMA1-Bcl10-MALT1 complex.

Karim Zubair A ZA Hensch Nicole R NR Qasim Hanan H Alshbool Fatima Z FZ Khasawneh Fadi T FT

Biochemical and biophysical research communications 20180414 2

The current work investigates the notion that inducible clustering of signaling mediators of the IKK pathway is important for platelet activation. Thus, while the CARMA1, Bcl10, and MALT1 (CBM) complex is essential for triggering IKK/NF-κB activation upon platelet stimulation, the signals that elicit its formation and downstream effector activation remain elusive. We demonstrate herein that IKKβ is involved in membrane fusion, and serves as a critical protein kinase required for initial formatio ...[more]

PMID: 29649481

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