Ontology highlight
ABSTRACT:
SUBMITTER: Qiao Q
PROVIDER: S-EPMC3929958 | biostudies-literature | 2013 Sep
REPOSITORIES: biostudies-literature
Qiao Qi Q Yang Chenghua C Zheng Chao C Fontán Lorena L David Liron L Yu Xiong X Bracken Clay C Rosen Monica M Melnick Ari A Egelman Edward H EH Wu Hao H
Molecular cell 20130901 6
The CARMA1/Bcl10/MALT1 (CBM) signalosome mediates antigen receptor-induced NF-κB signaling to regulate multiple lymphocyte functions. While CARMA1 and Bcl10 contain caspase recruitment domains (CARDs), MALT1 is a paracaspase with structural similarity to caspases. Here we show that the reconstituted CBM signalosome is a helical filamentous assembly in which substoichiometric CARMA1 nucleates Bcl10 filaments. Bcl10 filament formation is a highly cooperative process whose threshold is sensitized b ...[more]