Ontology highlight
ABSTRACT:
SUBMITTER: Shen W
PROVIDER: S-EPMC5928798 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Shen Wenzhi W Xie Junling J Zhao Shuangtao S Du Renle R Luo Xiaohe X He Huiwen H Jiang Shan S Hao Na N Chen Chong C Guo Chunlei C Liu Yanhua Y Chen Yanan Y Sun Peiqing P Yang Shengyong S Luo Na N Xiang Rong R Luo Yunping Y
Cancer letters 20180302
In this study, we present a medium throughput siRNA screen platform to identify inflammation genes that regulate cancer cell stemness. We identified several novel candidates that decrease OCT4 expression and reduce the ALDH + subpopulation both of which are characteristic of stemness. Furthermore, one of the novel candidates ICAM3 up-regulates in the ALDH + subpopulation, the side population and the developed spheres. ICAM3 knockdown reduces the side population, sphere formation and chemo-resist ...[more]