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Emerging Systemic Therapies for Colorectal Cancer.

ABSTRACT: Despite advances over the past 20 years in colorectal cancer (CRC) screening, diagnosis, and treatment, survival outcomes remain suboptimal. Five-year survival for patients with locally advanced CRC is 69%; 5-year survival drops to 12% for patients with metastatic disease. Novel, effective systemic therapies are needed to improve long-term outcomes. In this review, we describe currently available systemic therapies for the treatment of locally advanced and metastatic CRC and discuss emerging therapies, including encouraging advances in identifying novel targeted agents and exciting responses to immunotherapeutic agents.

SUBMITTER: Veenstra CM 

PROVIDER: S-EPMC5929883 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature

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Emerging Systemic Therapies for Colorectal Cancer.

Veenstra Christine M CM   Krauss John C JC  

Clinics in colon and rectal surgery 20180401 3

Despite advances over the past 20 years in colorectal cancer (CRC) screening, diagnosis, and treatment, survival outcomes remain suboptimal. Five-year survival for patients with locally advanced CRC is 69%; 5-year survival drops to 12% for patients with metastatic disease. Novel, effective systemic therapies are needed to improve long-term outcomes. In this review, we describe currently available systemic therapies for the treatment of locally advanced and metastatic CRC and discuss emerging the  ...[more]

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