Ontology highlight
ABSTRACT:
SUBMITTER: Buchanan AH
PROVIDER: S-EPMC5930270 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Buchanan Adam H AH Manickam Kandamurugu K Meyer Michelle N MN Wagner Jennifer K JK Hallquist Miranda L G MLG Williams Janet L JL Rahm Alanna Kulchak AK Williams Marc S MS Chen Zong-Ming E ZE Shah Chaitali K CK Garg Tullika K TK Lazzeri Amanda L AL Schwartz Marci L B MLB Lindbuchler D'Andra M DM Fan Audrey L AL Leeming Rosemary R Servano Pedro O PO Smith Ashlee L AL Vogel Victor G VG Abul-Husn Noura S NS Dewey Frederick E FE Lebo Matthew S MS Mason-Suares Heather M HM Ritchie Marylyn D MD Davis F Daniel FD Carey David J DJ Feinberg David T DT Faucett W Andrew WA Ledbetter David H DH Murray Michael F MF
Genetics in medicine : official journal of the American College of Medical Genetics 20171026 5
PurposeThe clinical utility of screening unselected individuals for pathogenic BRCA1/2 variants has not been established. Data on cancer risk management behaviors and diagnoses of BRCA1/2-associated cancers can help inform assessments of clinical utility.MethodsWhole-exome sequences of participants in the MyCode Community Health Initiative were reviewed for pathogenic/likely pathogenic BRCA1/2 variants. Clinically confirmed variants were disclosed to patient-participants and their clinicians. We ...[more]