Ontology highlight
ABSTRACT:
SUBMITTER: Hart NJ
PROVIDER: S-EPMC5931120 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Hart Nathaniel J NJ Aramandla Radhika R Poffenberger Gregory G Fayolle Cody C Thames Ariel H AH Bautista Austin A Spigelman Aliya F AF Babon Jenny Aurielle B JAB DeNicola Megan E ME Dadi Prasanna K PK Bush William S WS Balamurugan Appakalai N AN Brissova Marcela M Dai Chunhua C Prasad Nripesh N Bottino Rita R Jacobson David A DA Drumm Mitchell L ML Kent Sally C SC MacDonald Patrick E PE Powers Alvin C AC
JCI insight 20180419 8
Cystic fibrosis-related (CF-related) diabetes (CFRD) is an increasingly common and devastating comorbidity of CF, affecting approximately 35% of adults with CF. However, the underlying causes of CFRD are unclear. Here, we examined cystic fibrosis transmembrane conductance regulator (CFTR) islet expression and whether the CFTR participates in islet endocrine cell function using murine models of β cell CFTR deletion and normal and CF human pancreas and islets. Specific deletion of CFTR from murine ...[more]