Ontology highlight
ABSTRACT:
SUBMITTER: Wahlgren WY
PROVIDER: S-EPMC5931594 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Wahlgren Weixiao Y WY Dunevall Elin E North Rachel A RA Paz Aviv A Scalise Mariafrancesca M Bisignano Paola P Bengtsson-Palme Johan J Goyal Parveen P Goyal Parveen P Claesson Elin E Caing-Carlsson Rhawnie R Andersson Rebecka R Beis Konstantinos K Nilsson Ulf J UJ Farewell Anne A Pochini Lorena L Indiveri Cesare C Grabe Michael M Dobson Renwick C J RCJ Abramson Jeff J Ramaswamy S S Friemann Rosmarie R
Nature communications 20180501 1
Many pathogenic bacteria utilise sialic acids as an energy source or use them as an external coating to evade immune detection. As such, bacteria that colonise sialylated environments deploy specific transporters to mediate import of scavenged sialic acids. Here, we report a substrate-bound 1.95 Å resolution structure and subsequent characterisation of SiaT, a sialic acid transporter from Proteus mirabilis. SiaT is a secondary active transporter of the sodium solute symporter (SSS) family, which ...[more]